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Center for HIV Prevention Research (CPR)

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Publications

2015

McGowan I, Cranston RD, Duffill K, Siegel A, Engstrom JC, Nikiforov A, Jacobson C, Rehman KK, Elliott J, Khanukhova E, Abebe K, Mauck C, Spiegel HM, Dezzutti CS, Rohan LC, Marzinke MA, Hiruy H, Hendrix CW, Richardson-Harman N, Anton PA. A Phase 1 randomized, open label, rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of three formulations of Tenofovir 1% gel (the CHARM-01 Study). PLoS.One. 2015;10(5):e0125363. PMCID:PMC4420274

McGowan I, Anton PA, Elliott J, Cranston RD, Duffill K, Althouse AD, Hawkins KL, De Rosa SC. Exploring the feasibility of multi-site flow cytometric processing of gut associated lymphoid tissue with centralized data analysis for multi-site clinical trials. PLoS.One. 2015;10(5):e0126454

Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT. T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. PLoS.One. 2015;10(4):e0122723. PMCID:PMC4391713 

2014

Hoffman JC, Anton PA, Baldwin GC, Elliott J, Anisman-Posner D, Tanner K, Grogan T, Elashoff D, Sugar C, Yang OO, Hoffman RM. Seminal Plasma HIV-1 RNA Concentration Is Strongly Associated with Altered Levels of Seminal Plasma Interferon-gamma, Interleukin-17, and Interleukin-5. AIDS Res.Hum.Retroviruses 2014 Nov;30(11):1082-8. PMCID:PMC4208556

Yang KH, Hendrix C, Bumpus N, Elliott J, Tanner K, Mauck C, Cranston R, McGowan I, Richardson-Harman N, Anton PA, Kashuba AD. A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate. PLoS.One. 2014;9(10):e106196

Richardson-Harman N, Hendrix CW, Bumpus NN, Mauck C, Cranston RD, Yang K, Elliott J, Tanner K, McGowan I, Kashuba A, Anton PA. Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study. PLoS.One. 2014;9(10):e111507

Gorbach PM, Pines H, Javanbakht M, Weiss RE, Jeffries R, Cranston RD, Fuchs EJ, Hezerah M, Brown S, Voskanian A, Anton P. Order of Orifices: Sequence of Condom Use and Ejaculation by Orifice During Anal Intercourse Among Women: Implications for HIV Transmission. J.Acquir.Immune Defic.Syndr. 2014 Dec 1;67(4):424-9

Carballo-Diéguez, A, Giguere, R, Dolezal, C, Bauermeister, J, Cheng-Shiun, L, Valladares, J, Rohan, LC, Anton PA, Cranston, RD, Febo, I, Mayer, K, McGowan, I Rectal-specific microbicide applicator: Evaluation and comparison with a vaginal applicator used rectally. AIDS & Behavior, May 2014. Epub ahead of print: 10.1007/s10461-014-0793-0 [doi]

Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, et al. Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection. PLoS One 2014; 9(2):e8862. (PMC3928250)

Preza GC, Tanner K, Elliott J, Yang OO, Anton PA, Ochoa MT. Antigen Presenting Cell Candidates for HIV-1 Transmission in Human Distal Colonic Mucosa Defined By CD207 Dendritic Cells and CD209 Macrophages. AIDS Res Hum Retroviruses 2014; 30(3): 241-9. (PMC3938918)2013

2013

Lewis, MJ, Lee, P, Ibarrondo, FJ, Reed, D, Iyer, V, Ng, H, Elliott, J, Yang, OO, Anton, P HIV-1 Nef sequence and functional compartmentalization in the gut is not due to differential cytotoxic T lymphocyte selective pressure. PLOS One, 2013, Sep 13;8(9):e75620. (PMC3772905)

2012

Ibarrondo FJ, Wilson SB, Hultin LE, Shih R, Hausner MA, Hultin PM, et al. Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection. Mucosal Immunol 2012. 61:591-600. (PMC: 3865278)

Pines HA, Gorbach PM, Weiss RE, Hess K, Murphy R, Saunders T, et al. Acceptability of Potential Rectal Microbicide Delivery Systems for HIV Prevention: A Randomized Crossover Trial. AIDS Behav 2012; 17(8): 1002-1015. (PMC: 3594349)

Anton PA, Cranston RD, Kashuba A, Hendrix C, Bumpus NN, Richardson-Harman N, et al. RMP-02/MTN-006: A Phase 1 Rectal Safety, Acceptability, Pharmacokinetic and Pharmacodynamic Study of Tenofovir 1% Gel Compared to Oral Tenofovir Disoproxil Fumarate. AIDS Res Hum Retroviruses 2012; 28(11):1412-1421. (PMC: 3484811)

Richardson-Harman N, Mauck C, McGowan I, Anton P. Dose response relationship between tissue concentrations of UC781 and explant infectibility with HIV-1 in the RMP-01 rectal safety study. AIDS Res Hum Retroviruses 2012; 28(11):1422-1433. (PMC: 3484735)

McGowan I, Tanner K, Elliott J, Ibarrondo J, Khanukhova E, McDonald C, et al. Nonreproducibility of "Snap-Frozen" Rectal Biopsies for Later Use in Ex Vivo Explant Infectibility Studies. AIDS Res Hum Retroviruses 2012; 28(11) :1509-1512. (PMC: 3484788)

Burrell ER, Pines HA, Robbie E, Coleman L, Murphy RD, Hess KL, et al. Use of the Location-Based Social Networking Application GRINDR as a Recruitment Tool in Rectal Microbicide Development Research. AIDS Behav 2012; 16(7):1816-1820. (PMC:3692292)

Anton PA. Future prospects and perspectives on microbicides. Current HIV Research. 10;1, 113-115, 2012. (PMC:3804328)

2011

Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ. Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants. AIDS, 25;16:1971-1979, 2011. (PMID: 21811139)

Anton PA, Saunders T, Elliott J, Khanukhova E, Dennis R, Adler A, Cortina G, Tanner K, Boscardin J, Cumberland W, Zhou Y, Ventuneac A, Carballo-Diéguez A, Rabe L, McCormick T, Gabelnick H, Mauck C, McGowan I.  First Phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS ONE, 6(9): e23243, September 2011. (PMC3182160)

Anton P, Herold BC. (2011). HIV Transmission: Time for Translational Studies to Bridge the Gap. Sci Transl.Med. 3: 77ps11, 2011. (PMC:3767382)

2010

Ventuneac A, Carballo-Dieguez A, McGowan I, Dennis R, Adler A, Khanukhova E, Price C, Saunders T, Siboliban C, Anton P. Acceptability of UC781 gel as a rectal microbicide among HIV-uninfected women and men. AIDS Behav, 14;618-628,2010. (PMC:2865630)

Richardson-Harman N, Lackman-Smith C, Fletcher PS, Anton PA, Bremer JW, Dezzutti CS, Elliott J, Grivel JC, Guenthner P, Gupta P, Jones MS, Lurain NS, Margolis LB, Mohan S, Ratner D, Reichelderfer P, Roberts P, Shattock RJ, Cummins Jr JE. Multi-site comparison of an anti-HIV microbicide activity in explant assays using a novel endpoint analysis. Journal of Clinical Microbiology, 47;15:3530-3539, 2010. (PMC2772583)

2008

Anton PA, Ibarrondo FJ, Boscardin WJ, Zhou Y, Schwartz EJ, Ng HL, Hausner MA, Shih R, Elliott J, Hultin PM, Hultin LE, Price C, Fuerst MP, Adler A, Wong JT, Yang OO, Jamieson BD. Differential immunogenicity of vaccinia and HIV-1 components of recombinant vaccine in mucosal and blood compartments. Vaccine 18;26(35):4617-23, 2008. (PMC:2570228)

2007

McGowan I, Elliot J, Cortina G, Tanner K, Siboliban C, Adler A, Cho D, Boscardin WJ, Soto-Torres L, Anton P. Characterization of baseline intestinal mucosal indices of injury and inflammation in men for use in rectal microbicide Trials (HIV Prevention Trials Network-056). JAIDS, 2007 46;4:417-425. (PMID:17891044)

Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P.  HIV-1 pathogenesis differs in rectosigmoid and tonsilar tissues infected ex vivo with CCR5 and CXCR4-trophic HIV-1. AIDS, 2007 12:21(10):1263-72. (PMID:17545702)

2006

Jamieson BD, Ibarrondo FJ, Wong JT, Hausner MA, Ng HL, Fuerst M, Price C, Shih R, Elliott J, Hultin PM, Hultin LE, Anton PA and Yang OO. Transience of vaccine-induced HIV-1-specific CTL and definition of vaccine "response." Vaccine 2006;24:3426-3431. (PMID:16545508)

Fletcher PS, Elliott J, Grivel JC, Margolis L, Anton P, McGowan I, Shattock RJ. Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides. AIDS 2006;20:1237-1245. (PMID:16816551)

2005

Gurney KB, Elliott J, Nassanian H, Song C, Soilleux E, McGowan I, Anton PA and Lee B. Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa. J Virol 2005; 79(9):5762-5773. (PMC:1082722)

Ibarrondo FJ, Anton PA, Fuerst M, Ng HL, Wong JT, Matud J, Elliott J, Shih R, Hausner MA, Price C, Hultin LE, Hultin PM, Jamieson BD and Yang OO. Parallel Human Immunodeficiency Virus Type 1-Specific CD8+ T-Lymphocyte Responses in Blood and Mucosa during Chronic Infection. J Virol 2005; 79(7):4289-4297. (PMC1061549)

2004

McGowan I, Elliott J, Fuerst M, Taing P, Boscardin J, Poles M and Anton P. Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation. JAIDS. 2004; 37(2):1228-1236. (PM:15385729)

2003

Shacklett BL, Yang OO, Hausner MA, Elliot J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon DF, Anton PA and Jamieson BD. Optimization of methods to assess human mucosal T-cell responses to HIV infection and vaccination. J Immunol Methods 2003; 279;17-31. (PM:12969544)

2002

Deeks SG, Wagner B, Anton PA, Mitsuyasu RT, Scadden DT, Huang C, Macken C, Richman DD, Christopherson C, June CH, Lazar R, Broad DF, Jalali S and Hege KM. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Molecular Therapy 2002; 5(6):788-797. (PM:12027564)

Lehner T and Anton PA. Mucosal immunity and vaccination against HIV. AIDS 2002;16 Suppl 4:S125-S132. (PM:12699009)

Anton PA, Mitsuyasu RT, Deeks SG, Scadden DT, Wagner B, Huang C, Macken C, Richman DD, Christopherson C, Borellini F, Lazar R and Hege KM. Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS 2003; 17(1):53-63. (PM:12478069)

2001

Anton PA, Poles MA, Elliott J, Mao SH, McGowan I, Lenz HJ and Chen IS. Sensitive and reproducible quantitation of mucosal HIV-1 RNA and DNA viral burden in patients with detectable and undetectable plasma viral HIV-1 RNA using endoscopic biopsies. J Virol Methods 2001; 95(1-2):65-79. (PM:11377714)

Poles MA, Elliott J, Vingerhoets J, Michiels L, Scholliers A, Bloor S, Larder B, Hertogs K and Anton PA. Despite high concordance, distinct mutational and phenotypic drug resistance profiles in human immunodeficiency virus type 1 RNA are observed in gastrointestinal mucosal biopsy specimens and peripheral blood mononuclear cells compared with plasma. J Infect Dis 2001; 183(1):143-148. (PM:11087199)

2000

Olsson J, Poles M, Spetz AL, Elliott J, Hultin L, Giorgi J, Andersson J and Anton P. Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and beta-chemokines. J Infect Dis 2000; 182(6):1625-1635. (PM:11069233)

Anton PA, Elliott J, Poles MA, McGowan IM, Matud J, Hultin LE, Grovit-Ferbas K, Mackay CR, Chen ISY and Giorgi JV. Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS. 2000; 14(12):1761-1765. (PM:10985313)

 

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