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Center for Systems Biomedicine

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Publications

2015

Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Serebrennikova OB, Birli E, Choi J, Chang L, Anton PA, Tsichlis PN, Pothoulakis C, Verspaget HW, Iliopoulos D. MicroRNA214 is associated with progression of ulcerative colitis and inhibition reduces development of colitis and colitis-associated cancer in mice. Gastroenterology, 2015 [Epub ahead of print].
 
Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D. A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Inflamm Bowel Dis, 21: 996-1005, 2015.


2014

Iliopoulos, D. David Geffen School of Medicine at UCLA Poster. Click here to view poster »

Polytarchou C*, Koukos G*, Iliopoulos D. "Systems biology in inflammatory bowel diseases: ready for prime time." Curr Opin Gastroenterol. (2014) Jul 30(4):339-46. (*equal contribution)

Iliopoulos D. MicroRNA circuits regulate the cancer-inflammation link. Sci Signal, 7:pe8, 2014

Hatziapostolou M, Polytarchou C, Iliopoulos D. miRNAs link metabolic reprogramming to oncogenesis. Trends Endocrinol Metab, 24: 361-73, 2013.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell, 53: 577-90, 2014.


2013

Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D.MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology. 2013 Oct;145(4):842-52

Hatziapostolou M, Polytarchou C, Iliopoulos D. miRNAs link metabolic reprogramming to oncogenesis. Trends Endocrinol Metab, 24: 361-73, 2013.

He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell, 155: 384-96, 2013.

Hirsch HA, Iliopoulos D, Struhl. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA, 110: 972-7, 2013.

Drakaki A, Iliopoulos D. MicroRNA-gene signaling pathways in pancreatic cancer. Biomed J, 36: 200-8, 2013.

Drakaki A, Hatziapostolou M, Iliopoulos D. Therapeutically targeting microRNAs in liver cancer. Curr Pharm Des, 19: 1180-91, 2013.


2012

Polytarchou C, Iliopoulos D, Struhl K. Integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci USA, 109: 14470-5, 2012.  


2011

Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M & Iliopoulos D. An HNF4α-miRNA Inflammatory Feedback Circuit regulates Hepatocellular Oncogenesis. Cell, 147:1233-47, 2011.

 

Piskounova E, Polytarchou C, Hagan JP, Thornton JE, Triboulet R, Giacomelli C, Pothoulakis C, Iliopoulos D*, Gregory RI*. Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell, 147:1066-79, 2011 *corresponding authors

Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D, Pothoulakis C*. Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice and is Increased in Human Colon Tumors. Gastroenterology, 141:1749-61, 2011.

Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA, 108: 1397-402, 2011.  


2010

Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. Stat3 activation of miR-21 and miR-181b, via PTEN and CYLD, are part of the epigenetic switch linking inflammation to cancer. Mol Cell, 39:493-506, 2010. 

Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to Polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell, 39:761-72, 2010.

Hirsch HA*, Iliopoulos D*, Joshi A*, Zhang Y, Jaeger SA, Bulyk M, Liu SX, Struhl K. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-61, 2010 *equal contribution 


2009

Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation. Cell, 139:693-706, 2009. 

Androulidaki A*, Iliopoulos D*, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31:220-31, 2009. *equal contribution

Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Science Signaling, 2 (92): ra62, 2009.

Hirsch HA*, Iliopoulos D*, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res, 69:7507-11, 2009. *equal contribution

Drakaki A & Iliopoulos D. MicroRNA gene networks in oncogenesis. Curr. Genomics 10:35-41, 2009.

 

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